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NICE guidance on the assessment and management of overweight and obesity in adults (currently CG189 and associated updates) provides the overarching framework, alongside the technology appraisals for semaglutide 2
What we are reporting is that the pattern is consistent enough across our patient population to make us think the combination is worth considering in carefully selected cases, while acknowledging that we cannot yet quantify the effect with the rigour that randomized trial evidence would provide
For most patients, the first dose is administered in the week preceding further therapy, with follow-ups every few weeks to help alleviate symptoms and support better health outcomes
The mechanism of action of GLP-1 receptor agonists includes multiple pathways relevant to post-bariatric weight management
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